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Description
Priority Announcements on Doctoral Research Award competitions offer additional sources of funding for highly rated applications that are relevant to specific CIHR research priority areas or mandates. Applications are submitted through the October 2008 "2008(10)" competition of the Doctoral Research Award: 2008-2009 funding opportunity.
Doctoral Research Awards are intended to provide special recognition and support to students who are pursuing a PhD degree in a health-related field in Canada or abroad. These candidates are expected to have an exceptionally high potential for future research achievement and productivity.
Funds Available
CIHR's contribution to the amount available for this initiative is subject to availability of funds voted annually to CIHR by parliamentary appropriations, and the conditions that may be attached to them.
Funds Available for Research in All Areas:
Funds are available for applications in all areas of research that address any important health problem or issue through the October 2008 (2008-10) competition of the Doctoral Research Award: 2008-2009 funding opportunity.
Funds Available for Research in Specific Areas:
In this competition, funds are available to encourage and support applications in specific areas that are aligned with CIHR's research priority areas and mandates. Information on the research areas to be funded as well as the maximum amounts per grant that can be requested is found in the "Objectives" section.
A. CIHR Research Priority Areas
- Aging
- Amyotrophic Lateral Sclerosis
- Bioethics
- Clinical Research
- Digestive Health (Small Health Organization Partnership Program)
- Disability Prevention from Motor Vehicle Accidents (Small Health Organization Partnership Program)
- Fanconi Amenia (Small Health Organization Partnership Program)
- Genetics (Ethics, Law and Society)
- HIV/AIDS
- Knowledge Translation
- Mental Health/Addictions (Small Health Organization Partnership Program)
- Mind Foundation of BC (Small Health Organization Partnership Program)
- Occupational Therapy in Mobility in Aging (Small Health Organization Partnership Program)
- Parkinson's Disease
- Population Genetics, Genetic Epidemiology and Complex Diseases
- Regional Partnerships Program - Manitoba
- Regional Partnerships Program - New Brunswick
- Regional Partnerships Program - Newfoundland and Labrador
- Regional Partnerships Program - Prince Edward Island
- Thalassemia (Small Health Organization Partnership Program)
- Von Hippel-Lindau (Small Health Organization Partnership Program)
B. Prizes in CIHR Research Priority Areas
- Knowledge Translation - Jonathan Lomas KT Doctoral Award Supplement (Updated: 2008-08-20)
- Schizophrenia (Prize)
C. Priority Announcements announced after the launch
- Regional Partnerships Program - Saskatchewan (Updated: 2008-07-23)
- Huntington Disease (Updated: 2008-08-12)
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Objectives
The specific objective of the Doctoral Research Award Priority Announcement (Specific Research Areas) is to offer additional sources of funding for highly rated applications that are relevant to specific CIHR research priority areas and mandates.
A. CIHR Research Priority Areas
1. Aging. The CIHR Institute of Aging (CIHR-IA) will fund applications that are determined to be relevant1 to the research priority areas described below:
CIHR-IA will evaluate applications for relevance to Research on Aging Priority Topics which must be addressed within one relevance form (see "How to Apply").
The maximum amount awarded for a single award is $27,000 per annum for up to three years. CIHR anticipates that approximately four awards will be funded through this competition.
Within the context of the open CIHR Doctoral Research Award competition, the CIHR-IA will also award to the highest IA-relevant ranked applicant a travel allowance supplement valued at a maximum of $1,000 through the CIHR-IA Recognition Prize in Research on Aging.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
2. Amyotrophic Lateral Sclerosis. The Amyotrophic Lateral Sclerosis Society of Canada - ALS Canada in partnership with the CIHR Institute of Neurosciences, Mental Health and Addiction (CIHR-INMHA) will fund applications that are determined to be relevant to the research priority areas described below:
- Proteomics related to ALS
- Genomics related to ALS
- Motor neuron disease related to ALS
More information on the research priorities of the Amyotrophic Lateral Sclerosis Society of Canada on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. Approximately three awards will be funded through this competition.
Additional Requirements:
- Trainees must propose a research training program in Canada to be eligible for this award;
- Only one trainee per research environment will be eligible to receive funding.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
3. Bioethics. In memory of Dr. T. Douglas Kinsella, the CIHR Ethics Office in partnership with the CIHR Institute of Musculoskeletal Health and Arthritis (CIHR-IMHA) will fund applications that are determined to be relevant2 to the research priority area described below:
- Ethical issues related to health, health research and/or health policy
This funding opportunity is intended to provide recognition and funding to students whose research focuses on bioethics and to develop highly skilled and qualified researchers in the field of bioethics.
Ethics issues associated with health, health research or health policy must be the central focus of the proposed study, and may relate to ethics models, frameworks, concepts, principles or values, and/or the application of these. Scientific, social and legal issues, if addressed, should support the elucidation of the ethical issues.
More information on the research priorities of the CIHR Ethics Office can be found on their website.
The maximum amount awarded for a single award is $27,000 per annum for up to three years. CIHR anticipates that one award will be funded through this competition.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
4. Clinical Research. The CIHR Clinical Research Initiative will fund applications that are determined to be relevant to the research priority area described below:
More information on the research priorities of the CIHR Clinical Research Initiative can be found on their website.
The maximum amount awarded for a single award is $27,000 per annum for up to three years. CIHR anticipates that two awards will be funded through this competition.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
5. Digestive Health (Small Health Organization Partnership Program). CIHR through the Small Health Organization Partnership Program (SHOPP), in partnership with the Canadian Digestive Health Foundation (CDHF), will fund applications that are determined to be relevant to the research priority areas described below:
- Nutrition
- Liver disease
- Gastrointestinal disorders
- Digestive sciences
More information on the research priorities of the Canadian Digestive Health Foundation (CDHF) can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. Approximately three awards will be funded through this competition.
Additional Information:
- Award must be held in Canada.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
6. Disability Prevention from Motor Vehicle Accidents (Small Health Organization Partnership). CIHR, through the Small Health Organization Partnership Program (SHOPP), in partnership with the Canadian Institute for the Relief of Pain and Disability (CIRPD), will fund applications that are determined to be relevant to the research priority area described below:
- Disability prevention arising from motor vehicle collisions or manufacturing
More information on the research priorities of CIRPD can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. Approximately three awards will be funded through this competition.
Additional Information:
- Award must be held in Canada.
- CIRPD will not pay for parental leave but agrees to extend the term of the award by the duration of the leave.
- To be eligible for this award candidates must be registered HQP (Highly Qualified People) supported by the AUTO21 NCE and their research supervisor must be an AUTO21 network investigator. To confirm eligibility, candidates must submit with their application, a letter of support signed by their supervisor and a letter from AUTO21 confirming that they meet the above eligibility requirements. Candidates must contact Mrs. Sandra Bortolotti at AUTO21: Sandra.Bortolotti@auto21.ca.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
7. Fanconi Amenia (Small Health Organization Partnership Program). CIHR, through the Small Health Organization Partnership Program (SHOPP), in partnership with Fanconi Canada, will fund applications that are determined to be relevant to the research priority area described below:
More information on the research priorities of Fanconi Canada can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. It is anticipated that one award will be funded through this competition.
Additional Information:
- Award must be held in Canada
- Fanconi Canada will not pay for parental leave but agrees to extend the term of the award by the duration of the leave
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
8. Genetics (Ethics, Law and Society). The CIHR Institute of Genetics (CIHR-IG) will fund applications that are determined to be relevant to the research priority area described below:
- Genetics and Ethical, Legal and Social Issues
The IG wishes to fund applications that address ethical, legal, social issues relevant to the design, conduct and dissemination of genomic and genetic research; development and application of technologies, and their integration into society.
Suggested research areas include:
- Defining "populations" in genomics and genetics research
- Genetics, populations and public health
- Access to clinical applications (e.g., patenting, access to clinical trials, "right" to health care)
- Concepts of risk, communication, appreciation and evaluation
- Public understanding of science
- Defining "normalcy," "health," and "disease" in the genomics era
- Rights and responsibilities in relation to genomics and genetics
More information on the Research Priority Themes of CIHR-IG can be found in their strategic plan.
The maximum amount awarded for a single award is $ 27,000 per annum for up to three years. CIHR-IG anticipates that at least one award will be funded through this competition.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
9. HIV/AIDS. The CIHR Institute of Infection and Immunity - HIV/AIDS Research Initiative will fund applications that are determined to be relevant to the research priority areas described below (the primary research focus must be HIV/AIDS):
- Health systems, services and policy
- Resilience, vulnerability and determinants of health
- Prevention technologies and interventions
- Drug development, toxicities and resistance
- Pathogenesis
- Issues of co-infection
More information on the research priorities of the HIV/AIDS Research Initiative can be found on the Institute of Infection and Immunity website. Research in the priority areas described above that focuses on at risk populations including people living with HIV/AIDS, men who have sex with men, injection drug users, Aboriginal Peoples, prison inmates, youth at risk, women at risk and people from countries where HIV is endemic, is encouraged.
The maximum amount awarded for a single award is $27,000 per annum for up to three years. CIHR anticipates that approximately seven awards will be funded through this competition.
Additional Requirements:
- Applications to the HIV/AIDS Research Initiative are sought in two distinct funding streams - Biomedical/Clinical Research and Health Services/Population Health Research. Although projects which display a multidisciplinary approach across all four research pillars are strongly encouraged and accepted, applicants must clearly indicate the most relevant funding stream in the relevance field of their ResearchNet application.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
10. Knowledge Translation. The Knowledge Synthesis and Exchange Branch will fund applications that are determined to be relevant to the research priority areas described below:
- Increasing understanding of the theory and practice of KT
- Tools/measures to evaluate effectiveness/impact of KT practices/interventions
- Moving research into action (doing KT)
CIHR's mandate is to excel, according to internationally accepted standards of scientific excellence, in the creation of new knowledge and its translation into improved health for Canadians, more effective health services and products and a strengthened Canadian health care system. The purpose of this funding opportunity is to further strengthen knowledge translation (synthesis, dissemination, exchange and ethically sound application of knowledge) by supporting knowledge translation operating grants. It is expected that this targeted investment will lead to a better understand of concepts, theories and practices that underlie effect KT in order to improve the health of Canadian, provide more effective health services and products and strengthen the health care system.
More information on the research priorities of the Knowledge Synthesis and Exchange Branch their website.
The maximum amount awarded for a single award is $27,000.
Additional Information:
- The award is non-renewable.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
11. Mental Health/Addictions (Small Health Organization Partnership Program). CIHR, through the Small Health Organization Partnership Program (SHOPP), in partnership with the BC Mental Health Foundation will fund applications that are determined to be relevant to the research priority areas described below:
- Mental health
- Addictions
- Substance use
More information on the research priorities of the BC Mental Health Foundation their website.
The maximum amount awarded for a single award is $ 22,000 per annum for up to three years. It is anticipated that two awards will be funded through this competition.
Additional Information:
- Partner will not pay for parental leave but agrees to extend the term of the award by the duration of the leave
- One award will be offered in the field of mental health and one award will be offered in the field of addictions/substance abuse.
- Award must be held at a university located in British Columbia.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
12. Mind Foundation of BC (Small Health Organization Partnership Program). CIHR through the Small Health Organization Partnership Program (SHOPP), in partnership with the Mind Foundation of BC will fund applications that are determined to be relevant to the research priority areas described below:
More information on the research priorities of the Mind Foundation of BC can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. It is anticipated that one award will be funded through this competition.
Additional Information:
- Award must be held in British Columbia;
- Research to be conducted in British Columbia;
- Partner will not pay for parental leave but agrees to extend the term of the award by the duration of the leave.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
13. Occupational Therapy in Mobility in Aging (Small Health Organization Partnership Program). CIHR through the Small Health Organization Partnership Program (SHOPP), in partnership with the Canadian Occupational Therapy Foundation and the CIHR Institute of Aging Mobility in Aging Initiative, will fund applications that are determined to be relevant to the research priority area described below:
- Occupational therapy related research that addresses knowledge and knowledge to action gaps within the range of intrinsic and extrinsic challenges (from biological to environmental) associated with mobility of older Canadians. Research and research design should address issues of aging and/or the aged (generally above the age of 65) as essential elements of the objectives, hypotheses and analyses (e.g. dynamics of aging, age-relevant models and/or aged subject, uniqueness of aging or aged population).
More information on the research priorities of the Canadian Occupational Therapy Foundation can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. It is anticipated that one award will be funded through this competition.
Additional Information:
- Award must be held in Canada;
- The award offered to the successful applicant will be entitled: COTF/CIHR-IA/CIHR-PCE Doctoral Research Award in the Area of Occupational Therapy in Mobility in Aging.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
14. Parkinson's Disease. The Parkinson Society Canada in partnership with the CIHR Institute of Neurosciences, Mental Health and Addiction (CIHR-INMHA) will fund applications that are determined to be relevant to the research priority area4 described below:
- Psychosocial research in Parkinson's Disease
More information on the research priorities of the Parkinson Society Canada can be found on their Website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. CIHR anticipates that one award will be funded through this competition.
Additional Requirement:
- Award must be held in Canada.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
15. Population Genetics, Genetic Epidemiology and Complex Diseases. The CIHR Institute of Genetics (CIHR-IG) will fund applications that are determined to be relevant to the research priority area described below:
- Population Genetics, Genetic Epidemiology and Complex Diseases
The IG wishes to fund applications for projects that bridge laboratory-based research with genetic epidemiology. We encourage studies of special or high-risk populations which use novel molecular or statistical approaches or innovative designs.
Suggested research areas include, but are not restricted to:
- Genetic epidemiological studies of diseases in populations with distinct ethnic backgrounds or environmental exposures.
- Developing models for incorporation population history and structure which have implications for the study of genetic aspects of common diseases.
- Efficient designs for cohort studies to detect and model genetic effects and gene-environment interactions.
- Genetic modeling of complex phenotypes that exhibit quantitative variation.
More information on the Research Priority Themes of CIHR-IG can be found in their strategic plan.
The maximum amount awarded for a single award is $ 27,000 per annum for up to three years. CIHR-IG anticipates that at least one award will be funded through this competition.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
16. Regional Partnerships Program - Manitoba. CIHR, through the Regional Partnerships Program (RPP), in partnership with Manitoba Health Research Council may fund applications in Manitoba in all four pillars of research, subject to funding ability.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. Approximately one award is expected to be offered through this competition (subject to the availability of funds).
Additional Information:
- The award must be held in Manitoba
- The award is non-renewable under the RPP program
- Recipient will be the top ranked researcher that meets the above criteria
Please note researchers must submit their applications at least two weeks prior to the CIHR deadline to have their applications vetted by the internal review procedures at MHRC in order for their award to be eligible for consideration for RPP funding.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
17. Regional Partnerships Program - New Brunswick. CIHR, through the Regional Partnerships Program (RPP), in partnership with New Brunswick - RPP may fund applications in all four pillars of health research that contribute to the goal of building health research capacity in New Brunswick, which meet RPP eligibility requirements.
More information on the research priorities of New Brunswick can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. Approximately one award is expected to be offered through this competition (subject to the availability of funds).
Additional Information:
- The award is non-renewable under the RPP program
- The award must be held in New Brunswick
- Recipient will be the top ranked researcher that meets the above criteria
Please note that in order to be considered for RPP funding, researchers must have their applications screened through the internal review procedures of the New Brunswick RPP Advisory Board a minimum of two weeks prior to submitting their application to CIHR in order for their award to be eligible for consideration for RPP funding.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
18. Regional Partnerships Program - Newfoundland and Labrador. CIHR, through the Regional Partnerships Program (RPP), in partnership with Newfoundland and Labrador - RPP may fund applications in all four pillars of health research in Newfoundland and Labrador, pending funding availability, which meet RPP eligibility requirements.
More information on the research priorities of Newfoundland and Labrador can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. Approximately one award will be funded through this competition.
Additional Information:
- The award must be held in Newfoundland and Labrador
- The award is non-renewable under the RPP program
- Only one trainee will be eligible to receive funding with a single Principle Investigator
- Recipient will be the top ranked researcher that meets the above criteria
Please note that researchers must submit their applications at least one month prior to the CIHR deadline to have their applications vetted by the internal review procedures at RPP- Newfoundland and Labrador in order for their grant to be eligible for consideration for RPP funding.
Contact for this process is:
Office of Research and Graduate Studies,
Faculty of Medicine
Memorial University of Newfoundland
Room H-1759, Health Sciences Complex
St. John's, NL
A1B 3V6
Telephone: 709-777-6762
Fax: 709-777-7501
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
19. Regional Partnerships Program - Prince Edward Island. CIHR, through the Regional Partnerships Program (RPP), in partnership with Prince Edward Island - RPP may fund applications that span the four pillars of research that contribute to the goal of building health research capacity in PEI. The following areas of research strength at UPEI reflect the four pillars:
- Cardiovascular and respiratory health research
- Metabolism, Nutrition and Diabetes
- Human Development and Cognition
- Cancer Research
- Applied Health Services and Health Promotion
- Natural products and Human health
- Population Health
More information on the research priorities of Prince Edward Island can be found in the University of Prince Edward Island Strategic Plan.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. Approximately one award will be funded through this competition.
Additional Information:
- Only one trainee per research environment will be eligible to receive funding;
- The award must be held in Prince Edward Island;
- The award is non-renewable under the RPP program;
- Recipient will be the top ranked researcher that meets the above criteria.
Please note that in order to be considered for RPP funding, researchers must have their applications screened through the internal review procedures at the PEI Health Research Institute a minimum of one month prior to submitting their application to CIHR in order for their award to be eligible for consideration for RPP funding.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
20. Thalassemia (Small Health Organization Partnership Program). CIHR through the Small Health Organization Partnership Program (SHOPP), in partnership with the Thalassemia Foundation of Canada will fund applications that are determined to be relevant to the research priority area described below:
- Cardiovascular and respiratory health
- Metabolism
- Blood
More information on the research priorities of the Thalassemia Foundation of Canada can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. It is anticipated that one award will be funded through this competition.
Additional Information:
- Award must be held in Canada
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
21. Von Hippel-Lindau (Small Health Organization Partnership Program). CIHR through the Small Health Organization Partnership Program (SHOPP), in partnership with the Canadian VHL Family Alliance will fund applications that are determined to be relevant to the research priority area described below:
More information on the research priorities of the Canadian VHL Family Alliance can be found on their website.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. It is anticipated that one award will be funded through this competition.
Additional Information:
- Award must be held in Canada.
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
B. Prizes in CIHR Research Priority Areas
22. Knowledge Translation - Jonathan Lomas KT Doctoral Award Supplement. This award supplement is offered to an outstanding individual who is pursuing a Doctoral degree focused on Knowledge Translation.
A supplement will be offered to the highest ranked and funded candidate from the October 2008 Doctoral Research Award competition who has applied to, and been deemed relevant for, the Knowledge Translation Priority Announcement. The Jonathan Lomas KT Doctoral Award Supplement consists of a $5,000 supplement to the research allowance of a regular Doctoral Research Award. The supplement to the research allowance is intended to be used mainly for travel to national or international conferences, workshops or meetings related to the award recipient's research.
Jonathan Lomas is recognized as an international leader for his work exploring the role and impact of research evidence in health systems decision-making and is viewed in Canada as the godfather of knowledge translation. For more information on this prize, see the Knowledge Translation web site.
The maximum amount awarded for a single award supplement is up to $5,000 for one year. CIHR anticipates that one supplement will be offered through this competition.
(Updated: 2008-08-20)
In addition to the standard KT activities of presenting research findings to targeted audiences and producing lay summaries for dissemination, recipients of the KT award supplement are expected to undertake one of the following activities:
- Present at a CIHR summer institute, CIHR lunch and learn session, or KT trainee network event;
- Create a short podcast for posting on the CIHR website; or
- Carry out a clearly defined activity to be proposed to and approved by the Knowledge Synthesis and Exchange Branch.
Associated costs will be covered by CIHR and activities will be undertaken in coordination with the Knowledge Synthesis and Exchange Branch.
Additional Information:
- The award is non-renewable
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
23. Schizophrenia (Prize). In 1993, Dr. Michael Smith, who received the Nobel Prize for Chemistry in 1993 for his discovery and development of a crucial technique, known as site-directed mutagenesis, used in genetic engineering. His discovery enabled researchers to gain enormous insights into the structure and function of genes and proteins. Throughout his career, Dr. Smith strongly encouraged young people to pursue science as a career, and he has used his prize to promote science, encourage women to pursue interests in science and support research on severe mental illnesses, especially schizophrenia. To honor Dr. Smith's scientific accomplishments and his lifelong promotion of science, CIHR offers a Doctoral Research Award in his name (CIHR Michael Smith Doctoral Research Award for Research in Schizophrenia).
To be considered eligible for this award, the application must be relevant to the research priority areas described below:
- Genetics, molecular genetics, imaging and biochemistry of the central nervous system with application to schizophrenia;
The maximum amount awarded for a single award is $27,000 per annum for up to three years. One award will be funded through this competition.
Additional Information:
For questions about this research initiative and research objectives, see Appendix 1, under "More Information". For questions about, CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
C. Priority Announcements announced after the launch
(Updated: 2008-07-23)
24. Regional Partnerships Program - Saskatchewan (CIHR Research Priority Area)
CIHR, through the Regional Partnerships Program (RPP), in partnership with Saskatchewan - RPP may fund highly rated applications in Saskatchewan in all four pillars of research, subject to funding availability.
The maximum amount awarded for a single award is $22,000 per annum for up to three years. Approximately one to three awards are expected to be offered through this competition (subject to the availability of funds).
For additional information on eligibility criteria and funding details, please refer to Saskatchewan-CIHR RPP Policies.
Additional Information:
- The award must be held in Saskatchewan;
- The award is non-renewable under the RPP program;
- Recipient will be the top ranked researcher that meets the above criteria.
For questions about this research initiative and research objectives, see Appendix 1, under "Additional Information". For questions about CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
(Updated: 2008-08-12)
25. Huntington Disease. The Huntington Society of Canada (HSC) in partnership with the CIHR Institute of Neurosciences, Mental Health and Addiction (CIHR-INMHA) will fund applications that are determined to be relevant to the research priority area described below:
- Basic biomedical research in the area of Huntington's Disease
More information on the research priorities of HSC can be found on their website.
The maximum amount awarded for a single award is for $27,000 per annum for up to three years. CIHR anticipates that one award will be funded through this competition.
Additional Information:
- Award must be held in Canada.
- HSC will not pay for parental leave but agrees to extend the term of the award by the duration of the leave.
For questions about this research initiative and research objectives, see Appendix 1, under "Additional Information". For questions about CIHR funding guidelines, how to apply, and the peer review process, see the "Contact Information" section.
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Eligibility
Eligibility criteria for all CIHR research funding programs apply. The business office of the institution of an eligible Nominated Principal Applicant generally administers CIHR funds. Please refer to the Eligibility Requirements for CIHR Grants and Awards regarding the eligibility requirements for individuals and institutions.
Specific to CIHR training awards, please refer to the General Guidelines for Training Programs as well as the Doctoral Research Award: 2008-2009 program.
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Guidelines
This funding opportunity will follow the General Guidelines for Training Programs. Applicants are encouraged to demonstrate the use of Gender and Sex-Based Analysis in applications.
Allowable Costs
The awards consist of a stipend and a research allowance.
For the research allowance, awardees should review the Use of Grant Funds section of the Tri-Agency (CIHR, NSERC and SSHRC) Financial Administration Guide for a complete listing and description of allowable costs and activities.
Funding Requirements
The policies and requirements specified in CIHR General Grants and Awards Policies shall apply to applications funded through this funding opportunity. The policies and requirements cover areas such as Applicant and Institutional Responsibilities, Ethics, Official languages policy, Access to Information and Privacy Acts, and Acknowledgement of CIHR's Support. Successful applicants will be informed of any special financial requirements prior to the release of funds or when they receive CIHR's Authorization for Funding (AFF) document.
Access to Information Act and Privacy Act, and the Personal Information Protection and Electronic Documents Act (PIPEDA)
All personal information collected by CIHR about applicants is used to review applications, to recruit reviewers, to administer and monitor grants and awards, to compile statistics, and to promote and support health research in Canada. Consistent with these purposes, applicants should also expect that information collected by CIHR may be shared as described in Use and Disclosure of Personal Information Provided to CIHR for Peer Review.
CIHR as a federal entity is subject to the Access to Information Act and the Privacy Act, therefore the requirements of these two statutes will apply to all information located in CIHR's premises including, without limitation, cost-sharing agreements related to this funding opportunity and all matters pertaining thereto.
While respecting the application of the Privacy Act to federal entities, all signing parties involved in a collaborative agreement will also be bound by the Personal Information Protection and Electronic Documents Act (PIPEDA). All personal information (as identified by the PIPEDA) collected, used or disclosed in the course of any commercial activity under collaborative agreements related to the Funding opportunity will be collected, used and disclosed in compliance with the PIPEDA.
Communication Requirements
Grant recipients are required to acknowledge CIHR, its institutes and partners in any communication or publication related to the project. See CIHR General Grants and Awards Policies, Public Communication and Acknowledgement of CIHR's Support for details on CIHR's communication requirements. The contributing institutes / partners will be identified on the Authorization for Funding and decision letter.
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Performance Measurement
CIHR is committed to demonstrating results to Canadians for the money invested in health research. Therefore, processes for monitoring progress and appropriate use of funds, as well as for performance measurement and program evaluation are in place. As a result, funding recipients must:
- contribute to the monitoring, review and evaluation of CIHR's programs, policies and processes by participating in evaluation studies, surveys, workshops, audits and providing data or reports as required for the purpose of collecting information to assess progress and results;
- encourage their associates, trainees and administration to participate in the monitoring, review and evaluation of CIHR's programs, policies and processes as required.
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Review Process and Evaluation
Relevance Review
A. CIHR Research Priority Areas:
CIHR and partner organizations will provide funding for applications that are relevant to (in alignment with) the objectives and research priority areas described under "CIHR Research Priority Areas" within the "Objectives" section.
Relevance of the applications to the research priorities will be determined in the following manner.
Prior to peer review, CIHR and the partner organizations will review applications to determine the relevance, or alignment, of the research proposed to the research priority area(s) described above.
To conduct relevance review, these representatives will have access to a completed relevance form in addition to anonymized project titles and summaries, provided that applicants have consented to the sharing of information in consideration for other funding opportunities as well as to the sharing of information to observers in completing their ResearchNet application.
Upon completion of peer review, the CIHR and the partner organizations will receive the ratings, rankings and peer review committee recommendations on funding level and grant or award term for those applications that 1) are found to be relevant to the specific objectives of the research initiative and the research priority areas described under "CIHR Research Priority Areas"; and 2) are rated within the CIHR fundable range but are not funded through the regular CIHR competition to which they were submitted. These applications will be funded from the top down in order of ranking as far as budgets will allow. Applications that receive a ranking below 3.5 will not be funded.
Applications deemed relevant to a priority announcement, which are funded in the regular CIHR Doctoral Research Award competition or through a priority announcement will be named "Doctoral Research Award in the area of [specific research area] research" (e.g., "Doctoral Research Award in the area of aging research").
Peer review committees will not be informed of applications submitted for funding through this announcement.
B. Prizes in CIHR Research Priority Areas:
Upon completion of peer review, representatives of CIHR and/or partner organizations will receive an anonymized ranking list, funding level and peer review committee recommendations on grant term for all applications 1) that are funded in the regular CIHR Doctoral Research Award competition(s); and 2) that are identified as relevant through a keyword search. This information will be used to conduct relevance review when required and to determine the recipient(s) of the prize(s). These applications will be selected from the top down in order of ranking as far as budgets will allow. Applications that receive a rating below the regular CIHR Doctoral Research Award competition cut-off will not be considered for prizes.
Peer review committees will not be informed of applications submitted for funding through this announcement.
Peer Review
A CIHR peer review committee will evaluate the full applications. The committee may be drawn from one of CIHR's pre-existing committees or may be created specifically for this funding opportunity. Committee members are selected based on suggestions from many sources including the institute(s) / portfolio(s) and partner(s), following CIHR's Policy on Confidentiality, Conflict of Interest and Privacy Issues in Peer and Relevance Review (CCIP).
Evaluation Criteria
Doctoral Research Awards are reviewed in accordance with the Guide for Reviewers - CIHR Doctoral Research Awards.
The following general criteria for evaluating training award applications will be used:
- Achievements and Activities of the Candidate
- Characteristics and Abilities of the Candidate
- Research Training Environment
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How to Apply
Note: This funding opportunity requires the use of ResearchNet to apply for funding.
- A step-by-step overview of CIHR's application processes can be found under How to Apply for Funding.
- The application process for this funding opportunity is comprised of one step: Application.
- Applications are submitted through the October 2008 "2008(10)" competition of the Doctoral Research Award: 2008-2009 funding opportunity.
- To complete your Application, review the Doctoral Research Award: 2008-2009 funding opportunity and then follow the specific application guidelines and instructions which are fully described in its "How to Apply" section.
- Reminder to applicants: Please ensure that your application is complete (including all required signatures) and submitted on time to CIHR. Effective September 1, 2008, CIHR will assume no responsibility in following-up with applicants who submit an incomplete application. Incomplete or late applications will not be accepted into the competition.
Additional instructions that must be followed for this funding opportunity:
A. CIHR Research Priority Areas:
- Priority announcements for research in specific CIHR priority areas are listed in the "Objectives" section of this funding opportunity, under "CIHR Research Priority Areas."
- To apply for funding through these priority announcements, select the priority announcement title and relevant research area(s) addressed by your research proposal in the "Identify Priority Announcements and Relevant Research Area" section of your ResearchNet application.
- You may request that your application be considered for up to three priority announcement research areas per application, in each Doctoral Research Award competition.
B. Prizes in CIHR Research Priority Areas:
- Priority Announcement prizes are listed in the "Objectives" section of this funding opportunity.
- Your application will automatically be entered into Priority Announcement prize competitions. Refer to the "Review Process and Evaluation Criteria" section above for further details. Consideration for funding through priority announcements prizes is in addition to consideration for priority announcement funding in specific research priority areas.
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Contact Information
For questions on CIHR funding guidelines, how to apply, and the peer review process contact:
Natalie Carrière McGowan
Program Delivery Coordinator
Research Capacity Development
Canadian Institutes of Health Research
Telephone: 613-9546-1964
Email: natalie.carrieremcgowan@cihr-irsc.gc.ca
If you are experiencing technical difficulties with your ResearchNet account or the e-Submission process contact:
CIHR ResearchNet Support
Canadian Institutes of Health Research
Telephone: 613-941-9080
Email: support@researchnet-recherchenet.ca
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Additional Information
Appendix 1: Contacts for questions about specific priority announcements and their research objectives.
1. Aging
For questions about this initiative and research objectives contact:
Sharon Nadeau,
Associate, Strategic Initiatives, Institute of Aging
Canadian Institutes of Health Research
Telephone: 613-946-1270
Fax: 613-954-1800
E-mail : sharon.nadeau@cihr-irsc.gc.ca
2. Amyotrophic Lateral Sclerosis
For questions about this initiative and research objectives contact:
Barbara Beckett
Assistant Director, Institute of Neurosciences, Mental Health and Addiction
Canadian Institutes of Health Research
Telephone: 613-948-4877
Fax: 613-954-1800
E-mail: barbara.beckett@cihr-irsc.gc.ca
3. Bioethics
For questions about this initiative and research objectives contact:
Lynne Cayer
Ethics Policy Advisor, Ethics Office
Canadian Institutes of Health Research
Telephone: 613-952-4264
Fax: 613-954-1800
E-mail: lynne.cayer@cihr-irsc.gc.ca
4. Clinical Research
For questions about this initiative and research objectives contact:
Julie Senécal
Team Lead, Clinical Research Initiative
Canadian Institutes of Health Research
Telephone: 613-941-0057
Fax: 613-954-1800
E-mail: julie.senecal@cihr-irsc.gc.ca
5. Digestive Health (Small Health Organization Partnership Program)
For questions about this initiative and research objectives contact:
Allison Forsythe
Project Officer, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-941-6696
Fax: 613-954-1800
E-mail: allison.forsythe@cihr-irsc.gc.ca
6. Disability Prevention from Motor Vehicle Accidents (Small Health Organization Partnership Program)
For questions about this initiative and research objectives contact:
Allison Forsythe
Project Officer, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-941-6696
Fax: 613-954-1800
E-mail: allison.forsythe@cihr-irsc.gc.ca
7. Fanconi Amenia (Small Health Organization Partnership Program)
For questions about this initiative and research objectives contact:
Allison Forsythe
Project Officer, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-941-6696
Fax: 613-954-1800
E-mail: allison.forsythe@cihr-irsc.gc.ca
8. Genetics (Ethics, Law and Society).
For questions about this initiative and research objectives contact:
Ursula Danilczyk
Assistant Director, Institute of Genetics
Canadian Institutes of Health Research
Telephone: 416-813-7670
Fax: 416-813-7673
Email: ursulaig@sickkids.ca
9. HIV/AIDS
For questions about this initiative and research objectives contact:
Jennifer Ralph
Program Officer, HIV/AIDS Research Initiative
Canadian Institutes of Health Research
Telephone: 613-941-4464
Fax: 613-954-1800
E-mail: jennifer.ralph@cihr-irsc.gc.ca
10. Knowledge Translation
For questions about this initiative and research objectives contact:
Andrea Smith
Senior KSE Specialist - Knowledge Synthesis and Exchange Branch
Canadian Institutes of Health Research
Telephone: 613-948-2682
Fax: 613-954-1800
E-mail: andrea.smith@cihr-irsc.gc.ca
11. Mental Health/Addictions (Small Health Organization Partnership Program)
For questions about this initiative and research objectives contact:
Allison Forsythe
Project Officer, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-941-6696
Fax: 613-954-1800
E-mail: allison.forsythe@cihr-irsc.gc.ca
12. Mind Foundation of BC (Small Health Organization Partnership Program)
For questions about this initiative and research objectives contact:
Allison Forsythe
Project Officer, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-941-6696
Fax: 613-954-1800
E-mail: allison.forsythe@cihr-irsc.gc.ca
13. Occupational Therapy in Mobility in Aging (Small Health Organization Partnership Program)
For questions about this initiative and research objectives contact:
Allison Forsythe
Project Officer, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-941-6696
Fax: 613-954-1800
E-mail: allison.forsythe@cihr-irsc.gc.ca
14. Parkinson's Disease
For questions about this initiative and research objectives contact:
Ivy Lim-Carter
Manager, National Research & Clinical Programs
Parkinson Society Canada
Telephone: 416-227-3382 (direct line)
Fax: 416-227-9600
E-mail: ivy.lim-carter@parkinson.ca
15. Population Genetics, Genetic Epidemiology and Complex Diseases
For questions about this initiative and research objectives contact:
Ursula Danilczyk
Assistant Director; Institute of Genetics
Canadian Institutes of Health Research
Telephone: 416-813-7670
Fax: 416-813-7673
Email: ursulaig@sickkids.ca
16. Regional Partnerships Program - Manitoba
For additional information on eligibility criteria and funding details, please contact:
Shannon Rogalski
Manager, Funding Programs
Manitoba Health Research Council
Phone: 204-783-4249
Email: shannon.rogalski@mhrc.mb.ca
Website: www.mhrc.mb.ca
For questions on CIHR funding guidelines, how to apply, and the peer review process contact:
Jacqueline Jorge
Program Delivery Officer, Regional Partnerships Program
Canadian Institutes of Health Research
Room 97, 160 Elgin Street
Address Locator 4809A
Ottawa, ON, K1A 0W9
Telephone: 613-952-5728
Fax: 613-954-1800
E-mail : jacqueline.jorge@cihr-irsc.gc.ca
For questions about this initiative and research objectives contact:
Erik Blache
Senior Advisor, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-948-2684
Fax: 613-954-1800
E-mail: erik.blache@cihr-irsc.gc.ca
17. Regional Partnerships Program - New Brunswick
For questions about the NB RPP Advisory Board review process and criteria, please contact:
John Boyne
Administrator, Medical Research Fund of New Brunswick
P.O. Box 5100
520 King Street
Fredericton, NB, E3B 5G8
Telephone: 506-444-3222
Fax: 506-453-2958
E-mail: john.boyne@gnb.ca
For questions on CIHR funding guidelines, how to apply, and the peer review process contact:
Jacqueline Jorge
Program Delivery Officer, Regional Partnerships Program
Canadian Institutes of Health Research
Room 97, 160 Elgin Street
Address Locator 4809A
Ottawa, ON, K1A 0W9
Telephone: 613-952-5728
Fax: 613-954-1800
E-mail : jacqueline.jorge@cihr-irsc.gc.ca
For questions about this initiative and research objectives contact:
Erik Blache
Senior Advisor, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-948-2684
Fax: 613-954-1800
E-mail: erik.blache@cihr-irsc.gc.ca
18. Regional Partnerships Program - Newfoundland and Labrador
For questions on CIHR funding guidelines, how to apply, and the peer review process contact:
Jacqueline Jorge
Program Delivery Officer, Regional Partnerships Program
Canadian Institutes of Health Research
Room 97, 160 Elgin Street
Address Locator 4809A
Ottawa, ON, K1A 0W9
Telephone: 613-952-5728
Fax: 613-954-1800
E-mail : jacqueline.jorge@cihr-irsc.gc.ca
For questions about this initiative and research objectives contact:
Erik Blache
Senior Advisor, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-948-2684
Fax: 613-954-1800
E-mail: erik.blache@cihr-irsc.gc.ca
19. Regional Partnerships Program - Prince Edward Island
Please contact the following for additional information:
Colleen MacQuarrie
Acting Director Programs & Partnerships, PEI Health Research Institute
University of Prince Edward Island
550 University Avenue
Charlottetown, PE, C1A 4P3
Telephone: 902-894-2812
Fax: 902-628-4359
Email: peihri@upei.ca
For questions on CIHR funding guidelines, how to apply, and the peer review process contact:
Jacqueline Jorge
Program Delivery Officer, Regional Partnerships Program
Canadian Institutes of Health Research
Room 97, 160 Elgin Street
Address Locator 4809A
Ottawa, ON, K1A 0W9
Telephone: 613-952-5728
Fax: 613-954-1800
E-mail : jacqueline.jorge@cihr-irsc.gc.ca
For questions about this initiative and research objectives contact:
Erik Blache
Senior Advisor, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-948-2684
Fax: 613-954-1800
E-mail: erik.blache@cihr-irsc.gc.ca
20. Thalassemia (Small Health Organization Partnership Program)
For questions about this initiative and research objectives contact:
Allison Forsythe
Project Officer, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-941-6696
Fax: 613-954-1800
E-mail: allison.forsythe@cihr-irsc.gc.ca
21. Von Hippel-Lindau (Small Health Organization Partnership Program).
For questions about this initiative and research objectives contact:
Allison Forsythe
Project Officer, Partnerships and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-941-6696
Fax: 613-954-1800
E-mail: allison.forsythe@cihr-irsc.gc.ca
22. Knowledge Translation - Jonathan Lomas KT Doctoral Award Supplement
For questions about this initiative and research objectives contact:
Andrea Smith
Senior KSE Specialist - Knowledge Synthesis and Exchange Branch
Canadian Institutes of Health Research
Telephone: 613-948-2682
Fax: 613-954-1800
E-mail: andrea.smith@cihr-irsc.gc.ca
23. Schizophrenia (Prize)
For questions about this initiative and research objectives contact:
Natalie Carrière McGowan
Program Delivery Coordinator, Research Capacity Development
Canadian Institutes of Health Research
Telephone: 613-954-1964
Fax: 613-954-1800
E-mail: natalie.carrieremcgowan@cihr-irsc.gc.ca
24. Regional Partnerships Program - Saskatchewan (Updated: 2008-07-23)
For questions on CIHR funding guidelines, how to apply, and the peer review process contact:
Jacqueline Jorge
Program Delivery Officer, Regional Partnerships Program
Canadian Institutes of Health Research
Room 97, 160 Elgin Street
Address Locator 4809A
Ottawa, ON K1A 0W9
Telephone: 613-952-5728
E-mail: jacqueline.jorge@cihr-irsc.gc.ca
Erik Blache
Senior Advisor, Partnership and Citizen Engagement
Canadian Institutes of Health Research
Telephone: 613-948-2684
Fax: 613-954-1800
E-mail: erik.blache@cihr-irsc.gc.ca
25. Huntington Disease (Updated: 2008-08-12)
For questions about this initiative and research objectives contact:
Don Lamont
Huntington Society of Canada
151 Frederick Street, Suite 400
Kitchener, Ontario N2H 2M2
Telephone: 519-749-8491 ex. 24
E-mail: dlamont@huntingtonsociety.ca
1. Aging.
CIHR-IA will evaluate for relevance using the following criteria which must be addressed in separate paragraphs within the relevance field of your ResearchNet application.
- Criterion #1: Extent to which the proposal addresses one or more of the five IA priority topics;
- Criterion #2: Extent to which the research and research design address issues of aging and/or the aged are essential elements of the research objectives, hypotheses and analyses (e.g., dynamics of aging, age-relevant models and/or aged subjects; uniqueness of aging or aged population).
2. Bioethics. (Relevance Review Criteria):
Eligibility: Highest ranking CIHR Doctoral Research Award or Canada Graduate Scholarships Doctoral Award applicant whose research focuses on ethical issues related to health and/or health research.
Relevance review requirement: Determine if application is relevant or not; this is a "yes/no" decision. The ranking of applications is solely by peer review.
Relevance criteria:
- "Focus" on ethical issues related to health and/or health research: "Yes" means: Ethical issues related to health/health research (as defined below) are the central focus of the proposed study."No" means: Ethical issues related to health/health research (as defined below) not the central focus of the proposed study.
- "Ethical issues":
"Yes" means: Issues relating to ethics models, frameworks, concepts, principles or values, and/or the application of these. Scientific, social and legal issues, if addressed, support the elucidation of the ethical issues. "No" means: Ethical issues are not included in the proposed study; scientific, social and legal issues, if addressed, do not support the elucidation of ethical issues.
- "Health and/or Health Research": "Yes" means: Ethical issues (as defined above) are related to health (see the WHO definition) or to health research that is fundable by CIHR (see description in the CIHR Grants and Awards Guide). "No" means": The proposed study is not related to health or to health research.
3. Clinical Research.
Clinical Research is that part of the continuum of health research which is conducted on humans or on materials, specimens, or data derived from humans and populations with a focus on:
- Mechanisms of human health and disease;
- Bench to bedside to bench research;
- Clinical Trials and observational studies of prevention and therapy and;
- Clinical Epidemiological studies.
In addition, clinical research may utilize the methods of health care services/systems research and population health research as they relate to clinical encounters.
4. Parkinson's Disease.
The objectives of this award are to increase interest in Parkinson's disease and specifically to encourage young researchers in the area of psychosocial research in Parkinson's disease, as a complement to the biomedical research that is currently being funded.
Emphasis is placed on research directed towards closing the gap in understanding and treating non motor symptoms of Parkinson's and may involve qualitative and /or quantitative methodologies. Areas of interest in psychosocial research include but are not limited to:
- Research in the area of concurrency of psychiatric disorders including depression and drug/alcohol abuse amongst PLWP. Research can also focus on the psychological impact of PD on the spouse and family members, as well as individuals who live alone.
- Research that identifies best practice by focusing on the diagnosis and early treatment experiences of PLWP.
- Projects that focus on methods of improving support and access to services for people living with Parkinson's disease (PLWP). Groups include but are not limited to more advanced level PD caregivers, young onset and/or newly diagnosed individuals, individuals who live in rural area.
- Projects that focus on methods for improving appropriate services for PLWP from ethnic communities incorporating accommodation of language and cultural barriers.
- Research directed toward filling the gap in understanding and treating non motor symptoms of Parkinson's disease.
- Research directed to exploring the economic burden of PD on PLWP and their families. Research should include, but is not limited to, loss of income, cost of treatments, and comparison of impact on young versus older onset patients.
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